Head of Metabolism Disease

Strategic & Scientific Leadership · Define and execute the long-term research strategy for the metabolism disease portfolio, aligning with corporate goals and client needs, with direct input to the CSO and executive leadership. · Identify and validate novel targets with strong translational potential; champion innovative modalities including monoclonal antibodies, bispecifics, fusion proteins, peptides (cyclized, conjugated, or modified) , and novel scaffolds. · Stay at the forefront of metabolic disease biology and therapeutic trends; integrate emerging science into the discovery platform. Program & Portfolio Management · Oversee multiple discovery programs concurrently, ensuring timely delivery of key milestones (hit identification, lead optimization, candidate selection). · Lead the nomination of Preclinical Candidates (PCC) for both biologic and peptide assets, with a clear path to IND-enabling studies. · Collaborate closely with CMC, toxicology, and clinical development teams to advance molecules into first‑in‑human trials. Team Leadership & Talent Development · Directly manage and mentor a team of 6–8 PhD and MS‑level scientists, fostering a culture of scientific excellence, innovation, and collaboration. · Recruit, retain, and develop top talent; build a high‑performing, diverse team capable of tackling complex metabolic challenges. · Provide coaching and career development guidance to team members. External Engagement & Business Development · Represent the department in client meetings, due diligence, and scientific conferences; present program updates to internal governance committees and external partners. · Contribute to business development by identifying new collaboration opportunities and articulating our scientific capabilities. · Build and maintain strong relationships with academic and clinical experts in the metabolic field. ---

& Experience Education: · Ph.D. in Biochemistry, Molecular Biology, Pharmacology, or a closely related field. · Postdoctoral training in metabolic biology or a relevant discipline (strongly preferred). Professional Experience: · Minimum 12–15 years of overall industry experience in biologics or peptide drug discovery, with at least 8 years specifically in metabolic disease research (obesity, NAFLD/NASH, diabetes, or related areas). · Proven track record of successfully progressing biologic and/or peptide candidates from discovery to PCC nomination and entry into clinical trials (IND/CTA) – this is a non‑negotiable requirement. · Extensive hands‑on expertise in large‑molecule modalities: antibody engineering, bispecifics, Fc-fusion, peptide therapeutics (including cyclization, conjugation, formulation, and PK optimisation) , and novel scaffold platforms. · Deep understanding of metabolic disease pathophysiology, target biology, and translational biomarkers. · Strong knowledge of in vitro / in vivo pharmacology, developability assessment, and early CMC requirements for both biologics and peptides. Leadership & Soft Skills: · Demonstrated success in leading and growing a research team of at least 6–8 scientists, with evidence of effective people management, performance evaluation, and mentorship. · Excellent strategic thinking and decision‑making abilities; ability to balance scientific rigor with business priorities. · Outstanding communication and presentation skills in English (written and spoken); capable of influencing senior leadership (including the CSO) and external stakeholders. · Collaborative, client‑oriented mindset with a track record of successful cross‑functional and cross‑site collaboration. · Ability to thrive in a fast‑paced, matrixed environment and adapt to changing priorities.