质谱表征科学家(0924)

SUMMARY AND KEY ACCOUNTIBILITIES: Wuxi process development analytical science team is seeking a skilled and highly motivated candidate to fill a Scientist to Assistant Director level position (depending on candidate’s experience) in Wuxi. This position will work collaboratively in cross-functional teams on a range of programs. The candidate will work in a highly collaborative environment to utilize skills in partnership with internal and external experts. Oversee all aspects of structural characterization work of protein therapeutics, including but not limited to SEC, IEX, titer, CE-SDS, icIEF, mass spectrometry. Develop and implement novel LC-MS based analytical methods to support in-depth characterization of biologics and other new modalities (AAV, mRNA, oligonucleotide etc), including but not limited to intact mass, cIEF-MS, peptide mapping, disulfide mapping and glycan analysis. Support technical transfer, training and trouble-shooting of protein production for CMC development purposes.

You love analytics and are passionate about using data to drive key business decisions. You love learning new technological skills and working through collaboration. You will provide expertise in the field of in-depth protein analysis as it pertains to biologics characterization and other novel therapy related work with possibility to support other modalities as opportunities arise. Direct expertise in protein characterization or in mass spec-based proteomics (DDA, MRM, PRM et al.) is required. Previous experience in protein characterization of biologics and/or glycoproteins using peptide mapping, intact protein analysis is preferred. In-depth knowledge and hands-on experience in different types of analytical separation techniques and data processing analyses with focus on mass spectrometry applications. Knowledge of other analytical techniques such as chromatography (HPLC/UPLC), electrophoresis (CE-SDS, icIEF), biophysical methods and DNA analysis. Broad expertise and familiarity with protein, antibody production and CMC development. Thorough understanding of biochemistry and structural biology. Strong problem-solving and troubleshooting skills, capabilities in experimental design and execution, ability to work on multiple projects simultaneously, as well ability to work independently and collaborate cross-functionally.