上海睿智医药研究集团有限公司
Associate Director / Director of Protein Science
岗位职责
Provide strategic leadership in establishing and advancing the Protein Science function, including technology platforms, workflows, and capability expansion. • Lead, develop, and mentor a team of scientists (including PhD-level) to achieve high standards of scientific rigor, operational efficiency, and project delivery. • Oversee protein construct design, expression system selection, purification strategy, biophysical characterization, and transfer to downstream discovery, screening, CMC or structural biology teams. • Serve as the primary scientific lead for internal and external projects, including client interactions, project scoping, timelines, resource planning, and technical issue resolution. • Drive method optimization and platform innovation, including high-throughput expression, protein engineering approaches, and quality/lot-to-lot consistency standards. • Collaborate cross-functionally with Antibody Discovery, Protein Engineering, Structural Biology, ADC/Conjugation, Bioassay, and CMC teams to support integrated discovery and development programs. • Evaluate emerging technologies, establish strategic partnerships, and contribute to long-term R&D roadmap and investment planning. • Ensure compliance with organizational policies, data integrity requirements, and laboratory safety and quality standards.
任职要求
Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, Structural Biology, or related field; postdoctoral training or industry track record preferred. • 8+ years of relevant industry experience in recombinant protein expression and purification, with 3+ years of scientific team leadership. Experience in CRO/CDMO or biopharma drug discovery environments strongly preferred. • Demonstrated expertise in E. coli, insect, and/or mammalian expression systems, with proven ability to troubleshoot complex protein production challenges. • Strong understanding of protein biophysics and analytical methods (SEC-MALS, DSF, LC-MS, HPLC, thermal stability, glyco/protein quality profiling, etc.). • Proven ability to lead scientific teams, manage multi-project portfolios, engage with external partners, and deliver results on time and with high quality. • Excellent communication and presentation skills in both Chinese and English, with demonstrated experience interfacing with internal stakeholders and external collaborators/clients. • Highly motivated, strategic thinker with a track record of building high-performing teams and driving continuous improvement.
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