百济神州
研究员,临床前病理/Research Investigator, Pathology Research(博士)
岗位职责
We are seeking a pathologist to join the in vivo pharmacology team to support programs in preclinical and clinical development stages. The individual will bring pathology expertise with hands-on approaches to guide preclinical decisions and assist with decision making as programs move to clinical trials. The individual will help to optimize the histology and toxicology approaches, design studies and move the programs forward using high-quality tissue-based assays and data analysis. The individual will work cross-functionally with the project teams across a broad spectrum of portfolios including but not limited to Tumor Biology, Immuno-oncology and Non-oncology programs. Responsibility Build, organize and operate a translational pathology laboratory Being a vital member of the team to develop and optimize pathology methods for drug R&D. This includes, but not limited to, techniques used for molecular pathology, histology, investigative pathology/toxicology Drive high quality data analysis relevant to pathology and manage data generated both internally and externally Build a state-of-the-art pathology technology platform, including but not limited to, methods of IHC, IF and ISH to support characterization of established and novel targets. Guide pathology and imaging decision making with teams as drug candidates approach clinical stages Provide expert guidance on pathology and other tissue-based assays for cross functional research and development teams as needed Contribute to the implementation of pathology laboratory information & data management system Comply with regulated laboratory standards for pathology and IHC documentation and reporting standards Contribute to IND/NDA/CTA filing as the pharmacology/toxicology section author
任职要求
Position will be hired based on level of experience
Master or Ph.D. degree in molecular biology, cancer biology, pathology or related fields
Proven record of relevant experience and expertise in toxicology pathology or translational pathology work in drug discovery and/or development settings
Hands-on experience with a wide array of anatomic pathology laboratory platforms (e.g., histology, IHC/ISH/IF/multiplexing, light/fluorescent/confocal microscopy, digital pathology image analysis) across fresh frozen and paraffin-embedded formats
Experienced in assay development and optimization, and trouble-shooting of IHC/ISH/multiplexing assays and image analysis
Previous exposure to IND/CTA filing is a plus
Self-starter attitude, excellent interpersonal skills and comfortable in a fast pace biotech environment
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